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Best Nootropics Review – Top Brain Supplements & Smart Drugs


Nootropics are smart drugs that boost brain performance, enhance cognition and memory, and improve overall brain health. Nootropics can be natural, synthetic, or prescription substances. Nootropics work by supporting blood flow to the brain and will give you the mental edge needed for today’s hectic lifestyle, whether you are a college student, boardroom executive, entrepreneur, or athlete.

With the rise in popularity of nootropics, there are many products on the market to choose from. We rate the top 33 nootropic supplements for 2021.

The Top 33 Nootropic Brain Booster Supplements in 2021

We ranked the best science-backed nootropic supplements available today:

  • SANE Vitaae
  • Mind Lab Pro
  • Nuzena Neuro Focus +
  • NaturalCell NeuroActiv6
  • Noboru
  • Nootrogen
  • PureHealth Research Ageless Brain
  • Ageless Brain
  • Onnit’s Alpha Brain
  • Hunter Focus
  • Qualia Mind
  • Performance Lab Mind
  • CogniBiotics
  • Vital Plan Brain Boost
  • Synapse XT
  • NooCube
  • UpWellness Mind & Mood
  • Natural Stacks NeuroFuel
  • Puressence BrainEssence
  • Memo Defend
  • Brain C-13
  • Cymbiotika Golden Mind
  • Elm & Rye Nootropics
  • Amy Myers MD NeuroLive
  • Neuro
  • OptiMind
  • Youthful Brain
  • Oweli Neuro
  • ReMind Solution
  • BrainPill
  • ProMind Complex
  • Memory Hack
  • MemoSurge

SANE Vitaae

The SANE Laboratories manufactures one of the leading nootropic brands, Vitaae, which uses antioxidants like CoQ10 to target inflammation of the brain. Some of the unique benefits of this formula are a 13.6% increase in brain energy utilization and a 26% increase in membrane turnover.

Each capsule of SANE Vitaae includes folate, acetyl L-carnitine, omega-3 fatty acids, vitamin D, citicoline, and CoQ10. Each dose of Vitaae consists of three tablets, which means you get more active ingredients and an increase in cognitive response.

Vitaae is competitively priced and represents the budget-friendly options on our list. A daily dose of Vitaae will improve your mental focus and concentration, as well as improve your mood.

Mind Lab Pro

Mind Lab Pro is manufactured by Opti-Nutra, a supplement company with a team of medical experts on board, and is one of the top-rated nootropic brands. The board is led by a neuroscientist, Dr. Ramon Velazquez. Although more expensive than competing brands, Mind Lab Pro is the perfect introductory supplement for those looking to try a brain booster for the first time.

The Mind Lab Pro formula has been patented and contains advanced nutrients, including NutriGenesis vitamins that maximize absorption. Other vital ingredients include citicoline, phosphatidylserine, Rhodiola Rosea Extract, Bacopa Monnieri, and lion’s mane mushroom.

Mind Lab Pro offers substantial dosages as well as third-party testing, making it one of the best-rated nootropic formulas.

Nuzena Neuro Focus +

Nuzena’s Neuro Focus + is manufactured in the US and is a nutritional supplement that supports cognitive function, memory, and mental focus.

Each capsule of Neuro Focus + contains large amounts of minerals and multiple vitamins and 692mg of a proprietary blend. The unique formula in this blend contains glutamic acid, bilberry fruit extract, green tea extract, and other active ingredients.

Neuro Focus + costs around $60 per bottle, and you must buy a minimum of three bottles per purchase, making it one of the best-value nootropic supplements available today.


NooBru was launched in 2020 and was an immediate hit because of its tasty flavor, 13 active ingredients, and extensive media attention. The formula is famous amongst older adults, athletes, students, and entrepreneurs.

Noboru comes in powder form and contains vitamin B5, alpha GPC, L-theanine, Huperzine A, ashwagandha, choline bitartrate, and other proven ingredients. The NooBru formula is entirely transparent. Other nootropic supplements may hide the list of active ingredients within their formulas, but NooBru discloses all their components.

NooBru offers two options when purchasing their product, Shield or Advantage. Both are mixed with water or the beverage of your choice and enjoyed daily. Both versions of NooBru give you energy, improved cognition, focus, and clarity, and will boost your immunity.


The Nootrogen formula supports cognition, energy, focus, and stress. Two capsules daily will target your overall brain health.

Every serving of Nootrogen includes a 642mg proprietary formula containing amino acids, herbal extracts, and plant extracts, all proven to support brain function. Nootrogen also includes ingredients like glutamic acid, L-tyrosine, and DMAE.

Nootrogen is very affordable compared to competing brands, and the price-to-value ratio makes it an attractive option.

Ageless Brain

Ageless Brain, manufactured by Organixx, supports cognition by using unique active ingredients. These natural and unique ingredients include Cat’s claw, dragon’s blood, cacao, guayusa, Camu Camu, and cinnamon.

Ageless Brain is a good option for those who are looking to try something new and natural. More research is needed, however, to verify the effects of some of these ingredients.

Onnit’s Alpha Brain

Onnit’s Alpha Brain co-owner Joe Rogan promotes this brand which supports memory, focus, and daily cognition. The Onnit’s Alpha Brain formula has been thoroughly researched, clinically tested, and is peer-reviewed.

Onnit’s Alpha Brain contains natural ingredients like Cat’s claw and oat straw and Bacopa monnieri, Huperzia Serrata, and other elements that boost the brain. Onnit’s Alpha Brain uses proprietary formulas, and the manufacturer discloses individual dosages of most of the ingredients. At $35 per bottle, it’s also reasonably priced compared to other brands.

Hunter Focus

Roar Ambition manufactures Hunter Focus, and this nootropic supplement claims to give you an edge over the competition. Hunter Focus supplements contain all-natural ingredients and are a high-quality formula.

The key ingredients in this brain-boosting supplement include Bacopa monnieri, passionflower, and phosphatidylserine. The manufacturers promise an intelligent solution to mental fatigue and list all the natural ingredients in the formula.

Hunter Focus offers four capsules per serving, which is one of the highest dosages on our list. This brain booster continues to be one of the internet’s top-rated nootropic brands.

Qualia Mind

Neurohacker Collective manufactures Qualia Mind, a supplement that contains 28 brain health ingredients to support memory, focus, energy, and long-term brain health. The manufacturers offer a 100-day money-back guarantee, making it one of our list’s most extended guarantees.

Neurohacker Collective offers four brain-boosting supplements under their brand; Qualia Mind, Qualia Mind Caffeine Free, Qualia Mind Essentials, and Qualia Focus.


Performance Lab claims their product Mind boosts brain energy by 13.6% and supports focus and memory. Mind also claims to increase motivation and enhance recovery from intense cognitive exertion.

The Mind nootropic formula uses active ingredients like phosphatidylserine, L-tyrosine, citicoline, and maritime pine bark extract. These ingredients provide your body with vitamins, antioxidants, minerals, and other nutrients needed to support brain function.

Brain Boost

Dr. Bill Rawls from Vital Plan created Brain Boost. This nootropic supplement claims to help support cognitive function, memory, mental focus, and clarity. A daily dose of Brain Boost will also give you natural energy, improve your mood, relieve stress, and is excellent for your gut microbiome.

Brain Boost contains ingredients like Cat’s claw extract and lion’s mane mush, room as well as Bacopa monnieri, Ginkgo Biloba, and ashwagandha. Vital Plan lists all the active ingredients in Brain Boost and is one of the most potent formulas on our list, with four capsules per serving.


NeuroActiv6 is a nootropic supplement manufactured by NaturalCell. The formula comes in powder form and supports brain health, boosts clarity, and improves focus. One scoop of NeuroActiv6 daily can restore brain energy and promote neural communications. Another claim by the manufacturer NaturalCell, states an increase in healthy cortisol levels due to their supplement.

NeuroActiv6 list of ingredients includes a range of nootropic supplements and superfoods, such as turmeric, coffee fruit extract, ashwagandha, grape seed extract, and Vitamin B. NeuroActiv6 can be added to your daily smoothie and is cost-effective. NaturalCell offers a 60-day money-back guarantee.

Synapse XT

Synapse XT claims to support hearing and cognitive issues, making it popular amongst older adults. This nootropic formula includes a blend of vitamins, minerals, and plant-based ingredients to boost brain health.

Two capsules of Synapse XT daily will support hearing, memory and increase focus. The formula works by communicating between cells, and this minimizes the signs of brain fatigue. The price is mid-range, and this nootropic is perfect for the older generation looking to improve cognitive abilities and hearing.

NooCube Brain Productivity

Top neuroscientists developed NooCube Brain Productivity. NooCube’s Brain Productivity contains no caffeine, unlike other brain supplement brands. It uses plant and herbal extracts and other active ingredients to support brain health.

The main ingredients in NooCube Brain Productivity include Cat’s claw extract, Alpha GPC, Huperzine A, and Bacopa monnieri. The manufacturers offer a 60-day money-back guarantee on their supplements. NooCube’s Brain Productivity formula is priced at around $60 per bottle and delivers good value without compromising quality and ingredients.


Natural Stacks created NeurolFuel, and this nootropic supplement targets cognition, memory and helps you get rid of brain fog. NeuroFuel traces all ingredients and sources on the blockchain, making it the only “open source” nootropic listed here.

NeuroFuel uses active ingredients like forskolin, artichoke extract, acetyl L-carnitine, and vitamin B6 to target brain health. The formula contains 900mg of artichoke leaf extract, 750mg of acetyl L-carnitine, and 500mg of L-phenylaniline per serving. These substantial doses make it more effective than other formulas listed here. At $30, it also provides excellent value for money,

Mind & Mood

Mind & Mood is a nootropic supplement manufactured by UpWellness. Mind & Mood focuses mainly on anxiety, stress, and emotions, while other nootropic supplements generally support cognition, memory, and focus,

A daily dose of Mind & Mood means you can enjoy a calmer, stress-free life. The supplement supports emotional health by using ingredients like Rhodiola Rosea, GABA, saffron, 5-HTP, and L-theanine.


BrainEssence is a nootropic supplement from PureEssence and supports energy, memory, focus, clarity, and mood. The supplement comes in tablet form, and a daily dose of BrainEssence supplement will help support cognition in various ways.

Puressence lists all ingredients and dosages. It contains substantial doses of acetyl l-carnitine (500mg), Bacopa monnieri extract (300mg), and ashwagandha (200mg), along with smaller amounts of Rhodiola Rosea extract, alpha-lipoic acid, and Chinese club moss extract (with Huperzine A).

PureHealth Research Ageless Brain

There are two ‘Ageless Brain’ supplements on our list. The second supplement comes from PureHealth Research. PureHealth Research’s Ageless Brain offers a 365-day money-back guarantee and is a nutritional supplement formulated by Dr. Holly Lucillearend. The supplement contains B vitamins, GABA, caffeine, and Huperzine A, among other ingredients.

One capsule of Ageless Brain a day can decrease anxiety and brain fog, improve memory and focus, and boost cognitive wellness. Ageless Brain uses a proprietary formula: which means we don’t know the specific breakdown of each ingredient. However, if dosage transparency doesn’t bother you, Ageless Brain is one of the top options on our list.

Brain C-13

Brain C-13 from Zenith Labs is a nootropic supplement that contains vitamins, minerals, herbs, and plant extracts. Other ingredients include DMAE, rosemary leaf, turmeric, Rhodiola root extract, ginkgo leaf, Huperzine A, and phosphatidylserine.

Zenith Labs discloses all dosages and ingredients and dosages. A dosage of three capsules per serving is more substantial than some other supplements on our list. Brain C-13 was formulated by medical doctors and supported by a medical advisory board.

Cymbiotika Golden Mind

Golden Mind from Cymbiotika is the only nootropic formula that comes in a liquid form. Each serving of Golden Mind contains organic phosphatidylcholine, Rhodiola Rosea, lion’s mane powder extract, and L-theanine.

Golden Mind also contains unique ingredients like sea buckthorn oil, Gotu kola extract, and a combination of 82 ocean minerals. A daily dose of Golden Mind will reduce brain fog, protect and nurture brain cell growth, among other benefits.

Elm & Rye Nootropics

Elm & Rye manufactures a nootropic supplement called Nootropics. Nootropics are the most expensive supplement on our list. The variety of ingredients can improve memory and focus, support increased attention, and increase productivity and stamina.

Each dose of Nootropics contains GABA, bacopa monnieri extract, alpha GPC, L-theanine, L-tyrosine, B vitamins, and phosphatidylserine extract is equal to drinking 2 to 3 cups of coffee at once.


CogniBiotics works by optimizing digestion and not by explicitly targeting your brain. This nootropic blend claims to improve brain health, mental clarity, learning, memory, and focus.

CogniBiotics contains 17 adaptogenic herbs that boost cognitive function, mood, and stress by improving gut flora. Ten brain-friendly probiotic bacteria strains support bacteria levels in your gut.

Amy Myers MD NeuroLive

NeuroLive was formulated by Dr. Amy Myers, MD, and comes highly recommended as a nootropic brain booster supplement that acts as a premium cognitive enhancer. With seven high-profile brain-supporting micronutrients, the NeuroLive nootropic formula is one of the most effective products on the market today.

The proprietary blend contains Vitamin D, bacopa monnieri, whole plant extract, mucuna pruriens seed extract, ginkgo Biloba leaf extract, sharp-PS GREEN Phosphatidylserine, and N-Acetyl Tyrosine/L-Theanine, and offers complete brain support.

The ingredients used in NeuroLive are designed to provide a powerful assault against free radicals to help prevent oxidative damage. With the help of the Sharp•PS GREEN ingredient, the supplement supports a healthy vascular system with optimal blood flow. Shipping is free, and the manufacturers offer a 90-day return guarantee. NeuroLive underwent rigorous third-party lab tests and is a proven brand in the health market.


Neuro supplements are the only nootropic boosters that come in the form of mints and gums. By enjoying these gums or mints daily, you will feel calm, energized, and focussed.

Neuro offers three types of boosters; Energy & Focus, Calm & Clarity, and Ideal State. Whether you need a boost of energy in the morning or clarity in the afternoon, Neuro is the ideal supplement for you.

Neuro is the perfect choice for people who don’t like to swallow a tablet or capsule and is available in peppermint or cinnamon flavors. This supplement is also very affordable.


OptiMind boosts energy, focus, cognition, and mental clarity using proven ingredients. The principle active ingredient is Bacopa monnieri with bacosides; the active chemicals within the Bacopa monnieri plant give it its healing abilities. Taking OptiMind daily allows you to enjoy powerful cognitive support benefits.

Youthful Brain

Youthful Brain is created and produced by Vitality Now and supports mental energy, alert cognition, and general brain health. The multiple active ingredients found in Youthful Brain include Vitamin B12, Bacopa monnieri, and Huperzine A.

Youthful Brain contains similar ingredients to other leading brands, but it has lower dosages and a higher price tag.

Oweli Neuro

Oweli Neuro Brain & Focus Formula is also known as Neuro and is a unique supplement that promotes focus. Two capsules of Neuro a day can improve memory and learning and help fight age-induced cognitive decline.

Neuro contains ingredients that support concentration, memory, cognitive function, and productivity. Key elements in this formula include Huperzine A, phosphatidylserine, B vitamins, bacopa monnieri, inositol, and DMAE. Neuro also provides some of the best value for money on this list.

ReMind Solution

The ReMind Solution uses a clinically proven formula to fight anxiety, stress, and focus problems. ReMind’s main drawback is the price and value. The supplement provides few advantages over other supplements at this price range.

However, ReMind is backed by a 60-day money-back guarantee and further discounts are available when ordering 3 or 6 bottle packages of the formula.


BrainPill is recommended by Dr. Dave David and marketed as an “unfair advantage” over the competition. BrainPill claims to fight mental fatigue, protect and boost memory and eliminate brain fog. Other benefits of this brain booster include sustained cognitive energy and improved learning abilities.

BrainPill contains 13 nootropics for all-day focus and claims to boost cognition with no unwanted side effects. BrainPill does not contain caffeine; instead, the formula stimulates brainpower using active ingredients like L-theanine, citicoline, tyrosine, and vitamin B12.

The BrainPill formula is priced higher than other supplements despite having lower dosages. Unfortunately, the manufacturers do not disclose complete dosage information.

ProMind Complex

Carl Henderson created the ProMind Complex formula. He used his decades of experience to create the perfect nootropic formula. Despite claims made by Henderson and his team, ProMind Complex falls short based on its active ingredients and dosages.

ProMind Complex contains the following vital ingredients; L-glutamine, phosphatidylserine, bacopa monnieri extract, vinpocetine, and Huperzine A. These ingredients are proven for their nootropic effects; however, the dosage is very low given the high price of the supplement.

Memory Hack

Memory Hack is manufactured by Nutrition Hacks and is priced higher than the other competing supplements on our list. Regrettably, the ingredients and dosages do not justify the hefty price tag.

Memory Hack claims total restoration of memory in six months and may give people with memory disorders unrealistic expectations about the effects of their supplement. They offer a 60-day money-back guarantee, and all purchases come with a bonus guide, which could help you maximize the value of your purchase.


MemoSurge works in a three-step process. First, the supplement fires up the neurotransmitters in your brain. The formula then repairs damaged brain cells and eliminates brain shrinkage. Finally, the formula gets rid of anxiety and insomnia to boost your energy levels. The formula also claims to optimize your entire health and well-being.

MemoSurge provides limited information about its ingredients, concentrations, or dosages, making it difficult to compare the formula to other supplements listed here. MemoSurge may provide powerful benefits with few downsides, although the company offers limited information to support these claims.

Memo Defend

Memo Defend was created by a researcher named Thomas Taylor. His nootropic formula contains natural ingredients to support cognition and brain health in various ways.

Like other low-ranked supplements on our list, Memo Defend provides limited information about its ingredients or dosages. The formula consists of a 620mg proprietary blend with Hawthorn leaf, garlic bulb, and olive leaf. None of these ingredients has been linked to significant cognitive improvements in any notable studies to date. The most crucial element in Memo Defend is Vitamin B12, which is found in all nutritional supplements.

How the Best Nootropics and Top Smart Drug Pill Ratings Work

All nootropic supplements claim to be the best nootropics on the market today. To live up to these claims, we put them through rigorous scrutiny like combing through lab reports, consulting with our team, contacting manufacturers, and doing due diligence. Here’s how our editorial team ranked the best nootropic supplements.

Science-Backed Ingredients

After decades of research, plenty of evidence proves that plant extracts, vitamins, minerals, and herbal extracts can boost brain power and support cognition. We selected nootropics with science-backed ingredients and dosages and ranked them the highest when we created this list.

Effective Dosages

Many nootropic supplements contain the right ingredients but offer the wrong dosages. For example, a formula might have a dozen effective ingredients, yet the doses are too small to affect the human body significantly.

Transparent Advertised Benefits

Some nootropic companies exaggerate their benefits. They claim their formulas will make your brain decades younger, for example, and supercharge your memory and cognition, among other benefits. The best nootropic companies are honest and transparent with their advertised usefulness.

Proprietary Blends

Many manufacturers of nootropic supplements have a formula with a proprietary blend. These blends are frequently used to hide weak or lower dosages. Some companies even use proprietary blends to hide stimulants like caffeine. You might think a nootropic supplement is supercharging your cognitive energy, but actually, you’re just getting a 150mg dose of caffeine hidden within a 200mg proprietary blend.

Doctor Formulated or Approved by a Medical Advisory Board

Some of the leading nootropic supplements are formulated by real doctors, including medical doctors (MDs) or naturopaths (NDs). An in-house medical advisory board has approved other nootropic formulas. The more professional certifications a nootropic had, the higher it was ranked.

Manufacturer Reputation & Lab Testing

Some manufacturers have decades of experience creating effective supplement formulas, while others partner with third-party labs to test their formulas. Although we preferred manufacturers with a proven reputation for producing quality products, we weren’t biased towards older brands.

Customer Reviews & Subjective Experiences

Nootropic supplement works differently for every person, and that’s why we compared customer reviews and subjective experiences among our editorial team. We considered these reviews in our ratings.

Price & Value

Some people are willing to spend up to $200 per month on nootropic supplements. Others are looking for an edge for only $20 per month. We listed nootropic supplements that offer good value at any price.

Clinical Trials & Peer-Reviewed Research

Most nootropic supplement manufacturers do not invest in clinical trials. They are expensive and take a long time to produce results. However, as nootropics have become more popular, some companies have invested in clinical trials or published research in properly peer-reviewed journals, giving these companies that extra bit of legitimacy over competitors among nootropic supplement companies.

Money-Back Guarantee

The top nootropic supplement manufacturers back their formula with a moneyback guarantee. We preferred supplement companies that offered a satisfaction guarantee, moneyback guarantee, or similar promises to ensure the formula worked as advertised.

Nootropic Supplement Ingredients: What Does Science Say?

Nootropic supplement manufacturers make bold claims about their products and the possible effects and benefits. But do nootropic supplements work? How do nootropics work? What does science say about nootropics? Do clinical trials and peer-reviewed research back nootropics?

Today, the best nootropic supplements use proven ingredients to support cognition, memory, and overall brain health. Look for science-backed ingredients and dosages to ensure you’re getting the maximum benefits of your nootropic formula.

A few years ago, nootropics was an emerging field with little research. Today, you can find peer-reviewed research supporting specific nootropic formulas. Some of the best nootropic supplement ingredients are backed by decades of research and testing. We review some of the most used elements below and what the analysis says about their benefits.

Bacopa monnieri

Often, nootropic supplements contain Bacopa monnieri, a herbal extract used for many centuries in traditional Chinese medicine. In a 2001 study, researchers gave participants 300mg of Bacopa monnieri over 12 weeks and found that the herbal extract may improve cognitive processes and is particularly effective in enhancing learning and memory.

In a 2008 study, researchers found that a 300mg dose of Bacopa monnieri safely enhanced cognitive performance in older adults. This study also found that Bacopa monnieri improved information processing, reduced reaction times, and improved memory. Today, researchers know that the benefits of Bacopa monnieri are linked to bacosides. Some top-rated Bacopa monnieri supplements disclose their dosage upfront. Research shows that the best Bacopa monnieri dosage is around 300mg to 600mg per day.

Ginkgo biloba

Ginkgo biloba is another popular herbal extract found in many leading nootropic brands. Like Bacopa monnieri, ginkgo Biloba was used for centuries in traditional Chinese medicine and is now backed by modern scientific research. In a 2001 study, researchers gave ginkgo Biloba and vinpocetine (another nootropic ingredient) to participants for 14 days. Researchers observed faster response times and better memory in the ginkgo Biloba group compared to the placebo.


Ashwagandha is one of many adaptogens found in leading nootropic formulas. Ashwagandha is popular in traditional Indian medicine, used for relaxation, cardiovascular health, and stress management. In a 2016 study, researchers reviewed dozens of studies on ashwagandha and concluded the formula had “nootropic potential.” Researchers found that ashwagandha targets neurotoxins in the brain that impede memory and cognition.

Huperzine A

Huperzine A is another nootropic ingredient that has been extensively studied. In a 1999 study, researchers in China gave Huperzine A or a placebo to participants, then observed significant improvements in cognition, memory, and symptoms of Alzheimer’s Disease. Today, Huperzine A continues to be one of the most promising and science-backed nootropic ingredients, which is why it can be found in many nootropics listed above.


L-theanine is one of the most popular ingredients found in nootropics, and many people take caffeine and L-theanine daily for that extra brain boost. Taking 50mg of L-theanine, roughly the same amount found in two cups of brewed tea, increases alpha brain wave activity. Another study found that L-theanine complemented the effects of caffeine without the jitters and anxiety.


Most nootropics use ginseng (also labeled as Panax ginseng or Korean ginseng) to support cognition. A recent study found that taking 200mg to 400mg of ginseng reduced brain fatigue and improved brain performance.


We already take a daily nootropic, namely caffeine, the world’s most widely consumed stimulant. The energy-boosting effects of caffeine are well-known, but a 2021 study found that regular caffeine consumption temporarily changed your brain’s grey matter. Researchers analyzed a group of 20 healthy young individuals, then gave them caffeine or a placebo. Before and after the test, researchers performed a brain scan before and after the trial, finding significant differences in grey matter formation and brain electrical activity (EEG).

Clinical Trials

Onnit’s Alpha Brain is one of the few nootropic manufacturers that completed significant clinical trials on their formula. In a 2016 study published in Human Psychopharmacology, researchers gave Onnit’s Alpha Brain a placebo over six weeks to 63 participants between 18 and 35 years of age. Researchers found the Onnit’s Alpha Brain group had significant improvement in verbal memory.

Nootropic Dosages

Nootropic supplements contain different ingredients and come in powder form, tablets, capsules, or gum. It is essential to follow the recommended dosage instructions on your nootropic supplement.

Nootropics in capsule form are the most popular, and the dosage usually is two capsules once or twice per day. Powdered nootropic formulas are an easy and convenient way to take your supplement. Mix one scoop of powder with water, a shake, or the beverage of your choice, and drink daily to boost brain power.

Always check your choice of nootropic label for the proprietary formula. Most trustworthy nootropic supplements disclose their dosages. However, a few companies do continue to use proprietary labels. If you’re sensitive to caffeine, and if your nootropic supplement uses a proprietary formula containing caffeine, then be careful when using your nootropic supplement.

Nootropic Side Effects

When taking nootropics in recommended dosages, it’s rare for healthy adults to experience any significant side effects.

Some people do, however, experience mild digestive discomfort, nausea, and headaches. Stop using your nootropic immediately if you experience significant side effects.

If you follow the recommended dosage and have no underlying health conditions, then it’s unlikely you’ll experience any side effects from your nootropic supplement.

However, nootropics do contain unique plant-based ingredients and extracts, and it’s possible to experience allergic reactions to these ingredients.

Other nootropics contain caffeine which could cause jitters, anxiety, chest tightness, and nausea when taken at high doses.

It is advisable to talk to your doctor before taking a nootropic supplement if you take medication or have a medical condition.

FAQs About Nootropics

We get a lot of questions about nootropics and how they work. Here are some of our most commonly asked questions and answers:

Q: What is a nootropic?

A: A nootropic formula contains many natural ingredients such as vitamins, minerals, and plant extracts that boost brain function. These supplements come in the form of a drug, supplement, food, beverage, or other consumables.

Q: What do nootropics do?

A: Nootropics support brain health in different ways. Some boost your memory and also cognition. Others may increase energy by acting as a kind of stimulant. Some may even improve your executive functioning or assist brain plasticity in unique ways.

Q: How do I take nootropics?

A: It is now easier to take nootropics than ever before. Nootropics are available online, in stores, or through major online retailers like Amazon. Most nootropic dosages are one or two capsules per day with water. Other brands come in powder form, and some even offer your nootropic as gum or mint.

Q: What’s the best nootropic?

A: Any of the nootropic formulas on our list rate amongst the best supplements available in 2021.

Q: Where does the word ‘nootropic’ come from?

A: The term ‘nootropic’ was coined by a Romanian psychologist, Dr. Corneliu E. Giurgea, in the 1970s. He combined three Greek words, which roughly translates into “intelligence/mind turner.”

Q: Are nootropics safe?

A: All nootropic supplements sold online today must, by law, contain ingredients Generally Recognized As Safe (GRAS) by the FDA. When following the recommended dosage instructions on your supplement, you’re unlikely to experience safety issues or severe side effects. However, combining nootropics with drugs or experimenting with dosages could be unsafe. You should also talk to your doctor before taking a nootropic if you have a medical condition or take any medication.

Q: What are the side effects of nootropics?

A: Common side effects associated with nootropics include jitters, mild digestive issues, and headaches. However, most people experience no side effects when taking nootropics at the normal, recommended dosages.

Q: Why should I take a nootropic supplement? What are the benefits?

A: People take nootropic supplements to boost memory, cognition, and overall brain power. Some people target a specific issue, such as memory loss, while others seek general cognitive support and overall brain health.

Q: Who benefits from a nootropic supplement?

A: Athletes, people who work in competitive environments, college students, entrepreneurs, busy parents, older adults, and anyone looking for a cognitive edge can benefit from a nootropic supplement.

Q: How do I buy nootropics?

A: Today, nootropics are widely available online and offline. You can buy nootropics through Amazon and other major online retailers. You can even find nootropics at CVS, Walgreens, Walmart, and other brick-and-mortar retailers.

Q: Are nootropics legal?

A: Yes, nootropics are legal in all 50 states. To sell a supplement in the United States, the company must use ingredients and dosages Generally Recognized As Safe (GRAS) by the FDA. The FDA has verified that these ingredients and dosages are generally safe when used as intended.

Q: Are nootropics natural?

A: Most nootropics contain natural ingredients, including vitamins, minerals, plants, and herbal extracts. However, some nootropic ingredients are synthetic, which means they’re made in a lab. Check the label.

Q: Are nootropics vegan?

A: Most active nootropic ingredients are vegan, and no animal products are used in the formula. Some manufacturers package their ingredients into gelatin capsules instead of vegetarian capsules. Gelatin capsules are made from pork or beef by-products and are not vegan.

Q: Are nootropics addictive?

A: Nootropics are not considered to be habit-forming. Although you can get addicted to anything, nootropics do not have inherently addictive properties.

Q: Can I get a prescription for nootropics?

A: You do not need a prescription to buy nootropics. However, if you are dealing with severe memory issues or other cognitive problems, then a doctor may issue a prescription-strength drug to manage the condition.

Q: When should I take nootropics?

A: Most people take nootropics in the morning or early afternoon to support cognition during regular working hours. If your nootropic supplement contains stimulants, then it’s important to avoid using it late at night, as it could make it more difficult to fall asleep.

The Top 33 Nootropic Brain Booster Supplements in 2021 Final Word

Nootropic supplements have become increasingly popular, with more formulas available today than ever before.

Consumers can buy popular nootropic formulas at major online and offline retailers. A good nootropic supplement should optimize memory, cognition, focus, and overall brain health. This ultimate guide on the best nootropics contains the top-ranking brain boosters and cognitive enhancers on the market in 2021.

Whether you’re an athlete, older adult, office worker, or a student looking for an edge, any of the top-ranked nootropic supplements on our list may be a good choice. Our review is one of the most extensive nootropic reviews ever created, so make sure to bookmark this page as there will be plenty of updates and customer success stories to share. Our list for the top 33 best nootropic supplements to boost your brain offers something for everyone.

RELATED: 5 Best Adderall Alternatives: Top Natural OTC Brain Supplements

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The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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