Aging is a process that will ultimately impact anyone, but individuals over age 40 start to feel the effects that it can indeed cause. For that reason, anti-aging supplements have grown in popularity, which is why NAD+ boosters provide a new way to reduce the toll that aging has taken on the body.
Nicotinamide adenine dinucleotide (NAD) supplements focus on the cellular effect of aging, rather than just hiding wrinkles or improving the mind. These supplements are also known as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) supplements, and many major retailers already sell them.
How exactly do these formulas work? Which ones are the best for the benefits? That’s precisely what this guide plans to show. Take a look at the top NAD+ boosting supplements in 2021.
The Top NAD+ Supplements in 2021
After sifting through the many manufacturers and checking precisely what their remedies have in store, this list ultimately narrowed the top NAD+ boosters down to the following supplements:
- Tru Niagen
- Cymbiotika NMN
- Life Extension NAD+ Cell Regenerator
- Science.bio NR Chloride Powder
- Alive By Science
- Quicksilver Scientific Liposomal NAD+ Gold
- HPN Supplements NAD3 NAD+ Booster
- Toniq NMN
- Liftmode NMN
Read on below to see what each one provides users.
Tru Niagen is easily one of the most popular NAD+ boosters in this guide, improving cellular energy production with 500 mg of Niagen nicotinamide riboside (NR) in each capsule. This formula only requires that users take one capsule a day, regardless of the dosage size chosen. Users can get 300 mg or 500 mg concentrations to promote better wellness and reduce the damage to cell health. The packages range from $40 to $230.
Cymbiotika NMN offers users the chance to increase NAD+ production at just $80 for each bottle. Users will get the benefits of NMN, which is a precursor to NAD+. It is essential to increase NAD+ levels in the body, and users get all of the nutrients they need with the capsule offered.
In addition to NMN, this formula offers a few complimentary ingredients – apigenin, green tea, resveratrol, and green coffee bean. Users get a plethora of antioxidants, polyphenols, and other nutrients that are meant to boost these levels easily. By raising the NAD+ levels, users will find that their aging and cognition greatly benefit.
Elysium is the third of the most well-known remedies in the NAD+ supplement sector. It includes a B-vitamin complex patented by Oxford University, helping to slow the natural atrophy in the brain as individuals get older by potentially 86%. It also contains omega-3 fatty acids, antioxidants, and anthocyanins to ensure that users get all the nutrients they need.
Taking this formula daily is just one step. The purchase comes with a biological age test kit, allowing users to test before and after taking the supplement to prove the anti-aging benefits. Users can get two different formulas for NAD+ from the Elysium brand – Matter (to boost long-term brain health) and Basis (for overall anti-aging benefits). The company even has backed their supplements with clinical trials in humans. The total cost ranges from $50 to $70.
RiboGEN delivers NR to users with 300 mg in each serving. According to the makers of this supplement, it is the only brand that provides the same purity found in clinical and medical research studies. The formula offers similar benefits to the other remedies on the list, helping with NAD+ production. Plus, it is 99.5% concentrated with NR, combined with 0.5% NAM.
Users will get this formula for a relatively high price at $330, likely due to the high-quality NR found in the formula. Still, users will get 300 servings with every package, so they easily get good value for their investment.
Life Extension NAD+ Cell Regenerator
Life Extension NAD+ Cell Regenerator has direct statements on their bottle to verify precisely what NAD+ production can do for the body. Users get a 300 mg dose of NR, and every bottle also includes trans-resveratrol to help with the power of each ingredient. In doing so, they improve the boosting properties even further.
Individuals can reduce fatigue and improve their mitochondrial health better with the use of these formulas. They also reduce the effect of aging on the cells for just $45 per bottle. It offers plenty of value at such a low price, but it doesn’t sacrifice effectiveness to do so.
Science.bio NR Chloride Powder
Science.bio NR Chloride Powder is one of the most potent NR supplements available in this guide. Users can get the bottles for $30 to get 10 grams in a powder, but users can also filter the remedy into their capsules to get the benefits on their terms.
To ensure that consumers can fully trust this brand, the manufacturers put all products through lab testing. The batches and lots are coded to show customers full access to the lab reports, and the jar has even been manufactured to reduce the risk of UV damage while in storage. The total cost of this powder is $30.
Alive By Science
Alive By Science is a brand rather than a supplement. However, they are home to several NAD+ booster formulas that are unique. Even liposomal gels can significantly benefit users so that other remedies on this list simply can’t. Perhaps the most notable remedies from the brand are the NAD+ with Resveratrol LIPO Gel and the NMN with Resveratrol LIPO Gel. Typically costing around $75 per bottle, the remedies are taken sublingually to improve absorption.
For anyone that doesn’t like the gel texture, there are also powdered NMN and NAD+ booster supplements. The company offers capsules, leaving customers with their choice of supplementation for $50 to $80.
Quicksilver Scientific Liposomal NAD+ Gold
Quicksilver Scientific Liposomal NAD+ Gold focuses on increasing NAD to help users improve their cognition, energy levels, and the effect of aging on their bodies. Instead of capsules, users will take this formula as a liquid with their liposomal delivery system, making it easy for the body to accept into the bloodstream for faster absorption. Users just need to pump the formula twice into their mouth, holding the liquid for half a minute before swallowing.
This remedy uses NMN and other precursors to trigger the production of NAD+. It comes from one of the top-rated brands on the list, and it is available for $60.
HPN Supplements NAD3 NAD+ Booster
HPN Supplements NAD3 NAD+ Booster is unique and advertised as the “fountain of youth” for consumers. With 311 mg of the proprietary blend, users won’t get NR or NMN from this formula. Instead, they have a patent-pending formula called NAD3, offering theacrine, wasabi, and copper nicotinic acid to trigger higher NAD+ levels. Users can get a bottle of this formula for $60.
Toniq NMN has excellent packaging, which is a reflection of the high-quality product that they offer. Every bottle provides up to 99% of NMN the user needs to increase the production of NAD+ with 60 servings. Even with the purity level provided, users only have to pay $45 for this option. They can even get a larger bottle of 180 capsules at an equally affordable price. The purpose of this remedy is to target the production of NAD+ in the body.
Liftmode’s NMN focuses on delivering 10 grams of NMN, which is not made from vitamin B3. It is a synthetic ingredient that has consistently been linked to reducing the appearance of aging through its effect on NAD+ levels. It is easy to customize the dose for the user, but the company advertises explicitly that it can improve cellular energy, improve cognitive function, and more. This formula is in the form of a powder, which is available for $68 per jar.
How the Top NAD+ Supplements Were Ranked
Since so many NAD+ supplements are on the market, there had to be a way to narrow down the top remedies. Each says they offer anti-aging benefits, but only the products with the right ingredients and manufacturer made the cut. Here are the ranking factors that were considered as this guide was arranged.
Right now, scientists say that the top ingredients for improving NAD+ are NR and NMN. The formulas on this list had to include one of these ingredients, showing that they could trigger the production of NAD+. With clinically proven ingredients, formulas had the opportunity to be ranked higher.
Strength of Doses
While the right ingredients are essential, it is also crucial to have the proper dosages. Without enough potency, the formula is no better than a placebo. This list only included formulas that offer effective ingredients at the appropriate dosage.
Companies need to be honest about what they offer in each capsule. Companies that hide the actual ingredients from the label or their website are often not engaging in ethical practices. Genuine ingredient labels were prioritized for this list.
Since the details behind NAD+ boosting are still being studied, this type of formula still has a lot of room for change. According to studies, using ingredients like turmeric and resveratrol can boost NAD+, so many companies will also include these ingredients.
Having a reputation for honesty and effectiveness is essential, and companies like Niagen, Cymbiotika, and Elysium are some of the most reputable brands that the industry has seen. They’ve made these types of formulas for quite a while, and top companies have sought to prove the effectiveness of their ingredients with clinical trials.
Price & Value
Everyone wants to get good value for the money that they spend. Some people like to pay $30 for a supplement, while others willingly spend $200. To accommodate a range of budgets, this list includes formulas at many different prices.
The purpose of the majority of these products is to increase NAD+. However, some brands like to embellish what they do, claiming to help with unrealistic weight loss or reverse the appearance of aging by decades. Companies that made promises this big were not as preferred as companies with honesty and a realistic perspective.
Human Clinical Trials
Human clinical studies are in short supply in this industry, which is why they were so impressive to see from certain brands. Companies willing to invest in this kind of proof were more likely to use the evidence to create reliable remedies.
Top 4 Benefits of NAD+ Boosters
There are many reasons to take NAD+ booster supplements – let’s look at the top reasons consumers get involved with them.
Combat Age-Related Memory Loss
They say that memory is the first thing to go as consumers get older. Including a supplement that can help repair DNA and reduce neuronal stress is helpful to individuals who want to improve their memory recall.
Another problem that older consumers face is that their metabolism doesn’t work as quickly as it used to, making it difficult to maintain or lose weight. The use of an NAD+ supplement can help individuals that eat a high-fat diet, promoting weight loss.
Reverse the Effects of Aging
With all of the ways that NAD+ boosters support the body, perhaps the most popular is simply to reduce the overall effect of aging. These formulas won’t work within a night or two, but they will support the body to improve cells’ health.
Boost Muscle Strength and Endurance
It is pretty common to use NAD+ boosters to promote better performance during exercise, improving strength and endurance. It can also enhance muscle growth.
Top 5 Natural Ways to Boost NAD+ Levels
Even without taking an NAD+ supplement, it is still possible for consumers to improve their NAD+ levels. Some people use a booster, but specific changes to the user’s lifestyle can be equally effective. Here are the top ways to improve NAD+ levels naturally.
The top recommendation for consumers is to reduce calories. Some studies suggest cutting caloric intake by 20% to 30%. Even this reduction can improve the production of NAD+.
Fast or Practice Intermittent Fasting
Fasting is an easy way to improve NAD+ levels. By including both calorie restriction and fasting, consumers can increase their NAD+ production, which will help them enhance healthy aging and their lifespan.
Avoid Sun Damage
While consumers don’t necessarily have to avoid sunlight entirely, they should monitor how much exposure they get. The body automatically sends out NAD to repair sun damage, which means it can’t be used on the rest of the body. Make sure always to apply sunscreen or wear protective clothing to preserve the NAD+ in the body.
Practice HIIT Workouts
HIIT, or high-intensity interval training, is a type of workout that can increase the growth hormone, but it is also directly associated with NAD+ levels. These types of exercises can significantly benefit the mitochondria, but they also improve NAD+ levels.
Follow a Healthy Diet
No matter what other lifestyle changes an individual makes, they need to get enough essential vitamins, minerals, and other nutrients to maintain NAD+. Keep up with a balanced diet to keep NAD+ levels under control and manage how quickly aging occurs.
Top 5 Best Foods for Boosting NAD+ Levels
With certain nutrients, it is possible to increase NAD+ levels without the use of a supplement naturally. While the concentration won’t likely be as high, users can still have an impact. Fasting, reducing calories, and keeping up with a keto diet are helpful ways to improve the body naturally.
The top foods that users can consume to increase their NAD+ levels include:
- Milk, which offers a healthy source of NR.
- Fish, which has multiple NAD+ precursors.
- Mushrooms, which naturally boost NAD levels
- Green vegetables, which have many different vitamins and minerals that are necessary for NAD+ production
- Yeast and whole grains, which are high in NR and vitamin B3
Side Effects of NAD+ Boosters
Primarily, NAD+ boosters don’t have much of a side effect on adults, as long as the user follows the instructions provided on their supplement. The companies on this list abide by the Food and Drug Administration’s guidance on the dosages that are “Generally Recognized as Safe” (GRAS).
Individuals that are currently on medication may want to speak with their doctor or another medical professional to ensure that this type of supplement will not clash with the use of an NAD+ booster.
NAD+ Booster Dosage
The total dosage of an NAD+ booster will largely depend on the particular formula. The majority of the remedies here have approximately 300 mg of NR or the equivalent concentration of NMN. However, more research is being pursued to see precisely how much NMN is equivalent.
This amount of either precursor can help increase NAD+ levels, though even a dose as small as 100 mg can help. Some studies have even tested with amounts that are 1,000 mg of the precursory ingredients to enhance the production of NAD+ further.
Scientific Evidence for NAD+ Boosters
The use of NAD+ boosters is still relatively new, but new research grows every single day that shows exactly how these products can benefit aging consumers. They have a profound anti-aging effect, supporting the need to produce NAD without a bunch of synthetic ingredients that could cause more damage than good. More research is crucial to understand why and how they help, especially in humans.
For the most part, the examination of the use of NAD+ boosters has been with animals. For example, one study allowed researchers to see the effects of an NR supplement on mice with a genetic predisposition to have memory decline with age in the same way humans would. Mice given NR were able to produce new neurons easily, experiencing less DNA and neuronal damage. They also had higher neuroplasticity and lower DNA damage in the hippocampus, which is associated with memory.
A study that examined the effects of NAD+ boosters on mice found that it is possible to reduce the impact of a high-fat diet. Mice who got the NR supplement had 60% less weight gain than the mice given a placebo. Without the weight gain, the mice also had more energy, and their oxidative metabolism improved.
The use of an NR supplement could help consumers who want to raise their NAD+ levels, which means that their muscle function and strength will likely improve. Muscle function and strength suffer from age, and animal tests with mice reveal that using an NR supplement helps with these functions.
One of the other common effects of NAD+ booster is the improvement of repairing DNA. While this benefit may seem a little unclear, quite a few studies have backed up this claim. A supplement involving an NAD+ precursor was tested with researchers, finding that it only took a week to make noticeable improvements in muscle tissue. The muscle tissue between a two-year-old mouse and a four-year-old mouse was almost indiscernible, which backs up the idea that using an NAD+ precursor could reverse the impact of aging on cells.
Some studies focus on the way that NAD+ boosters can improve SIRT1 activation. This protein helps to promote mitochondrial function, according to yet another animal study on mice. However, using an NAD+ booster supplement is not the only way to increase the levels of this critical coenzyme.
Making small changes in diet and nutrition can have positive effects. According to recent studies, fasting or reducing calories can positively affect a body, as other lifestyle changes can. A study in 2014 discovered that even eating 30% fewer calories can increase NAD+ levels, and adding fasting improves the activation of SIRT1, leading to a longer lifespan. Keto dieting and intermittent fasting have been linked to the increase of NAD+ in the body, but more research needs to happen first.
Despite the many animal studies performed, some researchers have had human trials as well. A study published in Nature Communications discovered that adult humans could increase NAD+ and ADPR with NR supplementation. However, these kinds of trials are far and few between, which is why more research is crucial.
FAQs About NAD+ Boosters
Q: What is NAD?
A: NAD is an abbreviation for nicotinamide adenine dinucleotide. It is found in every cell for the cell’s metabolism, and it is a coenzyme. Primarily, it is seen as NAD+ and NADH.
Q: How are NAD, NAD+, and NADH different?
A: NAD, as described above, is the coenzyme associated with cell metabolism. NAD+ and NADH are two different forms of NAD. While NAD+ serves cell functions, NADH cannot perform the same processes.
Q: What does NAD+ do?
A: NAD+ helps with many different aspects of cell metabolism. It converts nutrients into ATP, which is then used to create energy.
Q: What is ATP?
A: ATP is an abbreviation for adenosine triphosphate. It is the energy that the cells use, which is created by the conversion that NAD+ initiates.
Q: What are sirtuins?
A: Like NAD, sirtuins are essential to multiple cellular processes. These proteins directly interact with NAD+, helping with gene expression, DNA repair, the preservation of the mitochondrial, and chromosomal maintenance.
Q: Why are consumers unable to keep the same NAD as they get older?
A: Keeping up energy levels and cellular health requires the constant production of NAD. The body declines in this production as it ages.
Q: How do consumers know if their NAD levels are too low?
A: Lethargy is one of the most common symptoms of low NAD. Since the cells need NAD to create energy, individuals without the same production will find it difficult to maintain physical or cognitive exertion.
Q: How will a NAD supplement help consumers?
A: The use of a supplement for NAD can help users reduce the impact of aging. Based on the science behind these supplements, cell cultures that receive NAD directly have helped reverse the aging process in animal studies. The formulas used today follow the same structure to ease stress and aging.
Q: What is a NAD booster?
A: This type of supplement is used to target the production of NAD in the body, reducing the damage that low production has caused. It can help with multiple areas of aging, and the boosters are used to counteract the areas that have become the most damaged from this natural change. They also increase NAD+ levels to promote better energy.
Q: What is nicotinamide riboside (NR)?
A: Nicotinamide riboside (NR) is a significant precursor to the biosynthesis of NAD. NR is necessary to the production of NAD+, but it is only one of two precursors.
Q: What is nicotinamide mononucleotide (NMN)?
A: Nicotinamide mononucleotide (NMN) is the other precursor involved with the biosynthesis of NAD. Much like NR, it is used to produce NAD+ for cellular energy.
Q: How do supplements with NMN and NR differ?
A: There is still a lot of research to be done on the different effects that consumers can achieve with the use of NMN versus NR supplements. Both of these components are precursors to NAD synthesis, so they are both effective.
Q: What are some ways that consumers can naturally increase NAD levels in their bodies?
A: Apart from using supplements, studies have shown that diet, exercise, and other healthy lifestyle changes can positively impact NAD levels. Consumers are encouraged to consume higher fats and low amounts of carbs to promote a better NAD+ level and to defend against oxidation. It can improve the anti-aging effect that NAD is known for. Some people use intermittent fasting to achieve these effects.
Q: Will participating in a HIIT (High-Intensity Interval Training) routine help with NAD+?
A: These workouts could help consumers to improve their NAD+ levels. Any type of workout that causes short bursts of high intensity for the body can help with growth hormone production. It also enhances NAD+ levels.
Q: Why can’t consumers use an NAD+ supplement with NAD+?
A: The majority of NAD+ boosters include the precursors to NAD+, which are NR and NMN. NAD+ cannot penetrate the cell walls, which is why these formulas have precursors instead.
Q: Will the use of niacin in a supplement increase NAD+?
A: This vitamin is known for naturally increasing NAD+ levels. Admittedly, it doesn’t have nearly the same effect as NR or NMN on NAD+ levels.
Q: Will NR increase NAD+ with greater success than NMN?
A: The majority of supplements that boost NAD+ levels will include NR rather than NMN. Some researchers (and some companies) believe that NMN’s absorption ability into the body is much like NAD+, which is too big. The use of vitamin B3 (niacin), nicotinamide, and NR is the easiest for the cell walls to accept.
Q: What side effects are associated with NAD+?
A: Most people do not have a negative side effect when taking on an NAD+ booster in their routine. Individuals that choose a remedy with high niacin levels may deal with itching, red skin, and potentially burning.
Q: What foods can consumers eat to increase their NAD+ levels naturally?
A: Milk, mushrooms, fish, and yeast are all helpful components in producing NAD and NAD+.
Q: Will exposure to sunlight impede the production of NAD+?
A: To fix the damage that sunlight can impose on the body, it needs NAD+. It can inhibit how much NAD+ is present in the body, but it won’t influence production.
Q: What benefits can consumers gain from NAD+ boosters?
A: The use of an NAD+ supplement can help with muscle strength, stamina, energy, liver health, immunity, sleep/wake cycles, mental acuity, and DNA repair.
Q: Why is it bad to have low NAD levels?
A: Someone with low NAD levels is putting their body at risk for weight gain, cardiovascular disease, lower metabolism, impaired brain function, and cell death. While aging is ultimately responsible for many of these effects, healthy lifestyle choices can help.
Q: What is NAD IV therapy work?
A: This type of therapy is an intravenous injection of NAD, and a health professional should only administer it.
Q: Which NAD+ supplement is the best one?
A: While Niagen, Elysium, and Cymbiotika are all relatively well known, any of the remedies on this list are excellent options.
The Top NAD+ Supplements in 2021 Final Thoughts
Nicotinamide adenine dinucleotide (NAD) is necessary to keep up with cellular energy needs. Using an NAD+ supplement can restore the depletion that the body experiences with age, improving endurance and cognition. In some cases, it can lead to weight loss and have other benefits as well. Since most of these supplements have the same promises, understanding each one is different helps greatly.
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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.